Vidastat

Vidastat

simvastatin

Manufacturer:

Therapharma

Distributor:

Unam
Concise Prescribing Info
Contents
Simvastatin
Indications/Uses
In CHD: Reduce risk of death; reduce risk of fatal & nonfatal MI; reduce incidence of stroke & transient ischemic attacks (TIA); reduce risk of undergoing myocardial revascularization procedures; slow progression of coronary atherosclerosis. In hyperlipidemia: Reduce total cholesterol, LDL-cholesterol, apolipoprotein B & triglycerides in patients w/ primary hypercholesterolemia, homozygous familial hypercholesterolemia & mixed dyslipidemia.
Dosage/Direction for Use
CHD Initially 20 mg/day as a single evening dose. Adjust at 4-wk intervals to a max of 80 mg/day. Hyperlipidemia Initially 10-20 mg daily as a single evening dose. Homozygous familial hypercholesterolemia 40 mg/day in the evening or 80 mg/day in 3 divided doses of 20 mg, 20 mg & an evening dose of 40 mg, Concomitant therapy In patients taking cyclosporine, fibrates or niacin concomitantly, max: 10 mg/day.
Administration
May be taken with or without food: Avoid excessive consumption (>1 L/day) of grapefruit juice.
Contraindications
Acute liver disease or unexplained persistent elevations of serum transaminases. Porphyria. Pregnancy & lactation.
Special Precautions
Measure liver enzymes before start of treatment & periodically thereafter for the 1st yr of treatment or until 1 yr after the last elevation in dose. Patients who consume substantial amounts of alcohol &/or have a history of liver disease.
Adverse Reactions
Constipation, dyspepsia, flatulence. Rarely, rhabdomyolysis.
Drug Interactions
Coumarin anticoagulants, digoxin, lopinavir & nelfinavir, itraconazole & ketoconazole, fibrates, niacin, cyclosporine, erythromycin, verapamil, diltiazem, grapefruit juice.
ATC Classification
C10AA01 - simvastatin ; Belongs to the class of HMG CoA reductase inhibitors. Used in the treatment of hyperlipidemia.
Presentation/Packing
Form
Vidastat tab 10 mg
Packing/Price
30's ($113.5/pack)
Form
Vidastat tab 40 mg
Packing/Price
30's
Form
Vidastat tab 20 mg
Packing/Price
30's ($168.5/pack)
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