Allergic reactions. Patients undergoing surgical procedures & in patients w/ trauma. Haemodynamic monitoring is required for vol & dose control. Avoid vol overload. Patients w/ pulmonary & cardiocirculatory problems; impaired hepatic function; blood coagulation disorders. Monitor serum electrolytes, fluid balance, renal function & blood coagulation parameters. Discontinue at the 1st sign of renal injury or coagulopathy. Patients undergoing open heart surgery in association w/ cardiopulmonary bypass. Pregnancy & lactation. Childn.