Generic Medicine Info
Organ allograft, severe cardiac disease and major organ dysfunction, CNS metastases, seizure disorder, abnormal serum bilirubin/creatinine, WBC <4,000/mm3, platelet <100,000/mm3, haematocrit <30%. Retreatment in patient who has experienced drug-related toxicities during previous course of therapy, including sustained ventricular tachycardia (≥5 beats), uncontrolled/unresponsive cardiac arrhythmia, chest pain (w/ ECG changes consistent of angina/MI), cardiac tamponade, intubation for ≥72 hr, renal failure requiring dialysis >72 hr, coma/toxic psychosis for >48 hr, bowel ischaemia/perforation, GI bleeding requiring surgery. Concomitant use w/ cisplatin, vinblastine, dacarbazine, and corticosteroids. Lactation.
Special Precautions
Patient w/ pre-existing cardiac or pulmonary disease, auto-immune disease (e.g. Crohn's disease), active infection, effusions from serosal surfaces, hypercalcaemia. Withhold treatment in patients who develop lethargy or somnolence during treatment. Hepatic and renal impairment. Pregnancy. Patient Counselling This drug may cause hallucination, somnolence, syncope, and convulsions, if affected, do not drive or operate machinery. Monitoring Parameters Monitor for wt, vital signs, fluid input/output, thyroid abnormalities or other autoimmune phenomena. Perform thallium stress test prior to treatment; baseline and periodic CBC w/ differential and platelet counts, blood chemistries (including electrolytes), chest x-ray, pulmonary function tests and arterial blood gas, renal and hepatic function tests.
Adverse Reactions
Tachycardia, arrhythmia, chest pain, myocardial ischaemia, cyanosis, transient ECG changes, palpitations; dyspnoea, cough, pulmonary oedema, pleural effusion, hypoxia, haemoptysis, epistaxis, nasal congestion, rhinitis; irritability, anxiety, depression, confusion, drowsiness, insomnia; nausea, diarrhoea, stomatitis, raised liver enzymes, GI disturbance, fever, flu-like symptoms (e.g. malaise, rigor, chills, arthralgia, myalgia), rashes, pruritus, dizziness, headache, paraesthesia, somnolence, neuropathy, syncope, speech disorder, taste loss, lethargy; leucopenia, anaemia, thrombocytopenia, eosinophilia, impaired neutrophil function; hypo- and hyperthyroidism; sepsis, bacterial endocarditis, peritonitis, pneumonia, catheter site infection; cerebral vasculitis. Rarely, leukoencephalopathy, uraemia, oliguria, anuria, resp failure, agranulocytosis, neutropenic fever, necrosis.
Potentially Fatal: Capillary leak syndrome resulting in hypotension, reduced organ perfusion, and oedema. Rarely, cholecystitis, liver failure.
Drug Interactions
Increased toxicity w/ hepatotoxic (e.g. methotrexate, asparaginase), nephrotoxic (e.g. aminoglycosides, indometacin), myelotoxic (e.g. cytotoxic chemotherapy), and cardiotoxic (e.g. doxorubicin) drugs in these organ systems. Delayed AR may occur w/ subsequent admin of iodinated contrast media. Increased renal toxicity w/ NSAIDs. May potentiate hypotension w/ β-blockers. May exacerbate autoimmune and inflammatory disorders (e.g. glomerulonephritis, thyroiditis, myasthenia gravis, Stevens-Johnson syndrome) and cause severe rhabdomolysis, MI, myocarditis, and ventricular hypokinesia w/ interferon-α.
ATC Classification
L03AC01 - aldesleukin ; Belongs to the class of interleukins. Used as immunostimulants.
Disclaimer: This information is independently developed by CIMS based on aldesleukin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by
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