Alfentanil


Generic Medicine Info
Contraindications
Obstructive airway disease, resp depression. Admin in labour or before clamping of cord during caesarean section. Concomitant use during or w/in 14 days of MAOI therapy.
Special Precautions
Patient w/ hypovolaemia, CV disease (e.g. acute MI), bradyarrhythmias, history of drug abuse or acute alcoholism, head injury, intracranial lesions, increased intracranial pressure, pulmonary disease, decreased resp reserve, compromised respiration, COPD or other obstructive pulmonary disease, kyphoscoliosis or other skeletal disorder, and compromised intracerebral compliance, hypothyroidism. Hepatic and renal impairment. Elderly and debilitated patients. Childn. Pregnancy and lactation. Patient Counselling This drug may cause impaired cognitive function, if affected, do not drive or operate machinery. Monitoring Parameters Continuously monitor vital signs, oxygen saturation, BP, and heart rate. Monitor the patient well after surgery for delayed effects.
Adverse Reactions
Significant: Hypotension, bradycardia, drug dependency, exaggerated elevation of intracranial pressure, skeletal muscle rigidity, fatigue, agitation. Nervous: Euphoric mood, disorientation; movement disorder, dizziness, sedation, dyskinesia, headache, somnolence, unresponsive to stimuli, loss of consciousness, convulsion, myoclonus, apnoea. CV: Tachycardia, arrhythmia, decreased heart rate, cardiac arrest, HTN. GI: Nausea, vomiting. Resp: Hiccups, laryngospasm, cough, hypercapnia. Ophthalmologic: Visual disturbance, miosis. Dermatologic: Dermatitis, hyperhidrosis, erythema, rash. Others: Chills, inj site pain, pyrexia.
Potentially Fatal: Resp depression.
Drug Interactions
Increased risk of prolonged/delayed resp depression w/ CYP3A4 isoenzyme inhibitors (e.g. ketoconazole, itraconazole, fluconazole, voriconazole, ritonavir, erythromycin, diltiazem, cimetidine). Enhanced resp depressant effect w/ barbiturates, benzodiazepines, neuroleptics, halogenic gases, and non-selective CNS depressants (e.g. alcohol). May increase blood concentration of propofol by 17%. May predispose to bradycardia or hypotension w/ drugs that depress the heart or increase vagal tone (e.g. β-blockers, anaesth agents). May cause bradycardia and cardiac arrest w/ non-vagolytic muscle relaxants.
ATC Classification
N01AH02 - alfentanil ; Belongs to the class of opioid anesthetics. Used as general anesthetics.
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