Generic Medicine Info
May be taken with or without food. Do not take w/ high fat meal.
Hypersensitivity; sulfonamide allergy. Oral solution: Infants, child <4 yr old; renal or hepatic failure; concomitant metronidazole or disulfiram therapy. Pregnancy and lactation.
Special Precautions
Elderly; renal impairment, hepatic impairment, DM, haemophilia; sensitivity to sulfonamides; use of sildenafil, vitamin E supplements. Always use with other antiretroviral agents in HIV treatment. Use oral solution only when capsule and other protease inhibitors are not therapeutic options. Capsule and oral solution not interchangeable on a mg-per-mg basis. Monitor for propylene glycol-associated adverse effect when oral solution is admin.
Adverse Reactions
Tremors, oral or perioral paraesthesia; mood disorders, dyslipidaemia, redistribution of body fat causing "protease paunch", buffalo hump, facial atrophy and breast enlargement; rash; GI effects e.g. nausea, vomiting and diarrhoea.
Potentially Fatal: Hypersensitivity, Stevens-Johnson syndrome and acute haemolytic anaemia.
Drug Interactions
Clorazepate, alprazolam, diazepam, erythromycin and midazolam increase risk of prolonged sedation and respiratory depression. Plasma concentrations of cilostazol, rifabutin, sertindole and terfenadine (risk of ventricular arrhythmias), sildenafil, antiarrhythmics may be increased. May increase warfarin effects. St. John's wort. Ethanol. Oestrogens; dexamethasone; delavirdine; efavirenz and veriparine; methadone.
CIMS Class
ATC Classification
J05AE05 - amprenavir ; Belongs to the class of protease inhibitors. Used in the systemic treatment of viral infections.
Disclaimer: This information is independently developed by CIMS based on amprenavir from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by
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