Butobarbital


Generic Medicine Info
Contraindications
Children, young adults, elderly and debilitated patients. Patients with depression or with a history of drug or alcohol abuse or addiction. Insomnia caused by pain. Acute porphyria. Severe hepatic impairment. History of CNS depression or coma, pulmonary insufficiency and sleep apnoea. Pregnancy & lactation.
Special Precautions
Renal impairment. Drowsiness may persist till the next day. Tolerance and dependence likely. Must not be withdrawn abruptly as withdrawal syndrome (including mortality) may occur.
Adverse Reactions
Drowsiness, ataxia, paradoxical excitement, confusion, headache and CNS depression; respiratory depression; GI disorders; hepatitis: fever; megaloblastic anaemia.
Potentially Fatal: Erythema multiforme; exfoliative dermatitis.
Drug Interactions
Butobarbital is a potent liver enzyme inducer and may reduce the effect of coumarin for up to 6 wk. Additive CNS depression with alcohol. Reduced effect of tricyclic antidepressants (such as amitriptyline, clomipramine, desipramine, dosulepin, imipramine, melitracen etc), corticosteriods (such as hydrocortisone, dexamethasone etc), coumarins, darifenacin, disopyramide, doxorubicin, metronidazole, theophylline and tolvaptan. It is also likely that the drug level of lidocaine is reduced due to the increased liver enzyme activity. May reduce drug level of memantine. Increased sedation with thalidomide.
Disclaimer: This information is independently developed by CIMS based on butobarbital from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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