Butorphanol


Generic Medicine Info
Contraindications
Significant resp depression, unmonitored acute or severe brochial asthma.
Special Precautions
Patient w/ head injury, increased intracranial pressure, acute MI, ventricular dysfunction, coronary insufficiency, adrenal insufficiency, biliary tract dysfunction, CNS depression, prostatic hyperplasia, hypercapnia/hypoxia, COPD, thyroid dysfunction; obese patients and those at risk for drug abuse. Renal and hepatic impairment. Elderly. Pregnancy (may cause neonatal opioid withdrawal syndrome in prolonged use during pregnancy) and lactation. Patient Counselling This drug may cause drowsiness and dizziness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor pain relief, resp and mental status, BP, signs and symptoms of hypogonadism or hypoadrenalism.
Adverse Reactions
Asthenia/lethargy, headache, heat sensation, vasodilation, palpitations, anorexia, constipation, dry mouth, nausea and vomiting, stomach pain, anxiety, confusion, dizziness, euphoria, floating feeling, insomnia, nervousness, paraesthesia, somnolence, tremor, bronchitis, cough, dyspnoea, epistaxis, nasal congestion, nasal irritation, pharyngitis, rhinitis, sweating, pruritus, blurred vision, ear pain, tinnitus, unpleasant taste, hypotension, syncope, abnormal dreams, agitation, dysphoria, hallucinations, hostility, rash, impaired urination, oedema, chest pain, HTN, tachycardia, depression, shallow breathing.
Potentially Fatal: Resp depression.
ROUTE(S) : IM / IV: C
ROUTE(S) : Nasal / Parenteral: C D if prolonged use/high doses at term.
Drug Interactions
Additive effect w/ other CNS depressants (e.g. general anaesth, phenothiazines or other tranquilizers, sedatives, hypnotics, antihistamines). May increase risk of transient high BP when used w/ sumatriptan nasal spray. Increased conjunctival changes when used w/ pancuronium. Decreased rate of absorption when used w/ oxymetazoline (nasal).
CIMS Class
ATC Classification
N02AF01 - butorphanol ; Belongs to the class of morphinan derivative opioids. Used to relieve pain.
Disclaimer: This information is independently developed by CIMS based on butorphanol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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