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Indications/Uses
Psychoses.
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Dosage/Direction for Use
Adult: PO 15-50 mg 3-4 times/day, up to ≥600 mg/day in severe conditions. IM 25-100 mg up to 4 times/day.
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Administration
May be taken with or without food. Take w/ meals or milk if GI upset occurs.
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Contraindications
Coma; CNS depression; pheochromocytoma.
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Special Precautions
Hepatic or renal impairment; history of jaundice; CV disease; angle-closure glaucoma; diabetes mellitus; hyperthyroidism; Parkinson's disease; epilepsy, depression, myasthenia gravis; prostatic hypertrophy; severe respiratory disease; blood dyscrasias. May precipitate coma, affect driving; elderly and children. Pregnancy and lactation
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Adverse Reactions
Dry mouth, constipation, urinary retention, mydriasis; agitation, insomnia, depression, convulsions, nasal congestion, tachycardia, postural hypotension, blurred vision, inhibition of ejaculation; urticaria, exfoliative dermatitis; agranulocytosis; extrapyramidal dysfunction; altered endocrine and metabolic functions.
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Drug Interactions
ACE inhibitors, α-blockers, amantadine, general anaesthetics, angiotensin-II receptor antagonists, antiarrhythmics, tricyclic antidepressants, anxiolytics and hypnotics, apomorphine, artemether with lumefantrine, barbiturates, bromocriptine, cabergoline, calcium-channel blockers, carbamazepine, cimetidine, ethosuximide, levodopa, lisuride, memantine, methyldopa, metoclopramide, opioid analgesics, oxcarbazepine, pergolide, phenytoin, pramipexole, primidone, ritonavir, ropinirole, sibutramine, sympathomimetics, terfenadine, tetrabenazine, tramadol and valproate. Alcohol.
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CIMS Class
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ATC Classification
N05AF03 - chlorprothixene ; Belongs to the class of thioxanthene derivatives antipsychotics.
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