Generic Medicine Info
Wolff-Parkinson-White syndrome; hypertrophic obstructive cardiomyopathy.
Special Precautions
CV disease; partial heart block, sinus node disorders, acute myocarditis, acute MI, advanced heart failure, severe pulmonary disease, thyroid dysfunction, hypokalaemia, hypomagnesaemia, hypercalcaemia, hypoxia, hypothyroidism, impaired renal function, elderly, premature infants. Maintain heart rate >60 beats/minute. withdraw 1-2 days before undergoing cardioversion. Not an appropriate form of therapy for any ventricular arrhythmia. Pregnancy.
Adverse Reactions
Nausea, vomiting, anorexia, diarrhoea, abdominal pain, headache, facial pain, fatigue, weakness, dizziness, drowsiness, disorientation, mental confusion, bad dreams, delirium, acute psychoses, hallucinations, convulsions, blurred vision, color vision may be affected, gynecomastia, vasoconstriction, and transient hypotension (rapid IV inj), local irritation (SC/IM), hypersensitivity reactions, thrombocytopenia.
Potentially Fatal: Heart failure, supraventricular or ventricular arrhythmias, conduction defects.
Drug Interactions
Thiazides, loop diuretics; corticosteroids; β2-agonists, amphotericin B; sodium polystyrene sulfonate; carbenoxolone; IV admin of calcium salts; quinidine; amiodarone; propafenone; other antiarrhythmics; β-blockers; calcium-channel blockers. Increased hepatic clearance by enzyme inducers e.g. rifampicin and aminoglutethimide.
CIMS Class
ATC Classification
C01AA04 - digitoxin ; Belongs to the class of digitalis glycosides. Used in the treatment of heart failure.
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