Estrone


Generic Medicine Info
Contraindications
Hypersensitivity; undiagnosed vaginal bleeding; thrombophlebitis or thromboembolic disorders; breast carcinoma except in selected patients being treated for metastatic disease; oestrogen-dependent tumor; porphyria; pregnancy.
Special Precautions
Conditions exacerbated by fluid retention; hypercalcaemia, CV and gallbladder disease; lipid effects; familial defects of lipoprotein metabolism. Children (premature closure of epiphyses). May increase BP, risk of venous thromboembolism, risk of breast cancer, size of preexisting uterine leiomyomata and risk of benign hepatic adenoma. Lactation. Vaginal tablet: Severe atrophic vaginal mucosa or following gynaecological surgery.
Adverse Reactions
GI disturbances, genitourinary changes, haematologic disorders, CV and CNS effects, endocrine and metabolic disorders, cholestatic jaundice, local skin reactions, chorea, contact lens intolerance, steeping of corneal curvature, pulmonary thromboembolism, carbohydrate intolerance.
Drug Interactions
Substrate of CYP1A2, 2A6, 2B6, 2C8/9, 2C19, 2D6, 2E1, 3A4; inhibits CYP1A2; induces CYP3A4. Effect decrease by rifampin, nelfinavir, ritonavir and anticonvulsants, folic acid.
ATC Classification
G03CA07 - estrone ; Belongs to the class of natural and semisynthetic estrogens used in estrogenic hormone preparations.
G03CC04 - estrone ; Belongs to the class of estrogens in combination with other drugs used in estrogenic hormone preparations.
Disclaimer: This information is independently developed by CIMS based on estrone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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