Indications/Uses
Listed in Dosage.
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Dosage/Direction for Use
Adult: PO Angina pectoris; Cardiac arrhythmias; HTN 25-50 mg 6-12 hrly. Max: 200 mg/day.
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Contraindications
CV shock, complicated acute MI; severe conduction disorders, sick sinus syndrome. Severe renal and hepatic insufficiency. Atrial fibrillation/flutter and simultaneous preexcitation syndrome e.g. Wolff-Parkinson-White syndrome.
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Special Precautions
1st degree AV block, bradycardia <50 beats/min, hypotension <90 mmHg systolic pressure, heart failure (previous compensation with cardiac glycosides/diuretics required). May impair ability to drive or operate machinery. Pregnancy (especially 1st trimester), lactation.
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Adverse Reactions
Rarely, nausea or vertigo, headache, hypotension, dizziness, flushing, bradycardiac arrhythmias, CHF, AV block. Very rarely, allergic skin reactions; reversible increase in transaminases and/or alkaline phosphatase, constipation; ankle oedema; gingival hyperplasia.
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Drug Interactions
CV effects enhanced by β-blockers, antiarrhythmics and other drugs with cardiodepressive effects on AV conduction. May intensify BP lowering effect of other antihypertensives. Simultaneous admin of IV β-blockers should be avoided. Digoxin, quinidine, carbamazepine, cimetidine, ranitidine, prazocin, midazolam, lithium, rifampicin, theophylline, phenytoin and phenobarbital may affect the plasma levels of gallopamil, May increase plasma conc of atenolol, metoprolol, propranolol.
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CIMS Class
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ATC Classification
C08DA02 - gallopamil ; Belongs to the class of phenylalkylamine derivative selective calcium-channel blockers with direct cardiac effects. Used in the treatment of cardiovascular diseases.
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