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Indications/Uses
Listed in Dosage.
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Dosage/Direction for Use
Adult: PO Giardiasis 100 mg 3 times/day for 5-7 days. Lupus erythematosus 100 mg once daily for the 1st 1-2 mth. Maintenance: 25-50 mg/day several times a wk. Intrapleural Prophylaxis of pneumothorax Instill 100 mg once daily for 3-4 consecutive days.
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Contraindications
Hypersensitivity; psoriasis.
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Special Precautions
Elderly, history of psychosis, hepatic disease, porphyria. Pregnancy and lactation.
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Adverse Reactions
Dizziness, headache; nausea, vomiting; reversible yellow discolouration of the skin, conjunctiva, urine (on prolonged use); blue-black discolouration of the palate and nails; psychosis, CNS stimulation, convulsions; ocular toxicity chronic dermatoses; rarely, liver toxicity and aplastic anaemia.
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Drug Interactions
May produce disulfiram-type reaction with alcohol. May increase plasma concentrations and toxicity of primaquine.
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ATC Classification
P01AX05 - mepacrine ; Belongs to the class of other agents used in the treatment amoebiasis and other protozoal diseases.
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