Penbutolol


Generic Medicine Info
Administration
May be taken with or without food.
Contraindications
AV block (2nd and 3rd degree), sinus bradycardia, bronchial asthma, cardiogenic shock.
Special Precautions
Bronchospastic disease, compensated heart failure, DM, myasthenia gravis, untreated phaeochromocytoma, peripheral vascular disease including Raynaud's disease. May mask signs and symptoms of hyperthyroidism and acute hypoglycaemia. Avoid abrupt withdrawal as it may precipitate thyroid storm, exacerbate angina, HTN and MI. Patients undergoing surgery involving general anaesth. Pregnancy and lactation. Monitoring Parameters Monitor BP and heart rate.
Adverse Reactions
Headache, dizziness, fatigue, insomnia, asthenia, arrhythmia, diaphoresis, CHF, nausea, diarrhoea, dyspepsia, upper resp tract infection, dyspnoea, cough, chest and limb pain, excessive sweating, impotence.
Drug Interactions
Concomitant use w/ digitalis glycosides may increase the risk of bradycardia. Hypoglycaemic effects of insulin and antidiabetics may be prolonged. Coadministration w/ Ca antagonist may lead to synergistic hypotensive effects, bradycardia and arrhythmias. Additive effects w/ anaesth agents that depress the myocardium (e.g. cyclopropane, ether, trichloroethylene). Catecholamine-depleting drugs (e.g. reserpine) may enhance hypotensive effects. May enhance the rebound hypertensive effect of clonidine.
CIMS Class
ATC Classification
C07AA23 - penbutolol ; Belongs to the class of non-selective beta-blocking agents. Used in the treatment of cardiovascular diseases.
Disclaimer: This information is independently developed by CIMS based on penbutolol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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