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Indications/Uses
Listed in Dosage.
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Dosage/Direction for Use
Adult: PO Vitamin A deficiency For severe deficiency w/ corneal changes: 500,000 u/day for 3 days, followed by 50,000 u/day for 2 wk and then 10,000-20,000 u/day for 2 mth as follow-up therapy. For cases w/o corneal changes: 10,000-25,000 u/day until clinical improvement occurs (usually 1-2 wk). IM Patients w/ biliary cirrhosis or chronic cholestatic disease 100,000 u 2-4 mthly. Topical Acne; Psoriasis As cream/oint: Apply as directed.
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Administration
Should be taken with food.
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Contraindications
Hypervitaminosis A; pregnancy (dose exceeding RDA).
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Special Precautions
Cholestatic jaundice; fat-malabsorption conditions. Monitor patients closely for toxicity. Liver impairment and children.
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Adverse Reactions
Hypervitaminosis A characterised by fatigue, irritability, anorexia, weight loss, vomiting and other GI disturbances, low-grade fever, hepatosplenomegaly, skin changes, alopoecia, dry hair, cracking and bleeding lips, SC swelling, nocturia, pains in bones and joints.
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Drug Interactions
Decreased absorption with neomycin. Increased risk of hypervitaminosis A with synthetic retinoids eg, acitretin, isotretinoin and tretinoin. Increased risk of toxicity when used with alcohol.
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ATC Classification
R01AX02 - retinol ; Belongs to the class of other nasal preparations for topical use.
S01XA02 - retinol ; Belongs to the class of other ophthalmologicals. D10AD02 - retinol ; Belongs to the class of topical retinoid preparations used in the treatment of acne. |
