Retinol


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult: PO Vitamin A deficiency For severe deficiency w/ corneal changes: 500,000 u/day for 3 days, followed by 50,000 u/day for 2 wk and then 10,000-20,000 u/day for 2 mth as follow-up therapy. For cases w/o corneal changes: 10,000-25,000 u/day until clinical improvement occurs (usually 1-2 wk). IM Patients w/ biliary cirrhosis or chronic cholestatic disease 100,000 u 2-4 mthly. Topical Acne; Psoriasis As cream/oint: Apply as directed.
Administration
Should be taken with food.
Contraindications
Hypervitaminosis A; pregnancy (dose exceeding RDA).
Special Precautions
Cholestatic jaundice; fat-malabsorption conditions. Monitor patients closely for toxicity. Liver impairment and children.
Adverse Reactions
Hypervitaminosis A characterised by fatigue, irritability, anorexia, weight loss, vomiting and other GI disturbances, low-grade fever, hepatosplenomegaly, skin changes, alopoecia, dry hair, cracking and bleeding lips, SC swelling, nocturia, pains in bones and joints.
Drug Interactions
Decreased absorption with neomycin. Increased risk of hypervitaminosis A with synthetic retinoids eg, acitretin, isotretinoin and tretinoin. Increased risk of toxicity when used with alcohol.
ATC Classification
R01AX02 - retinol ; Belongs to the class of other nasal preparations for topical use.
S01XA02 - retinol ; Belongs to the class of other ophthalmologicals.
D10AD02 - retinol ; Belongs to the class of topical retinoid preparations used in the treatment of acne.
Disclaimer: This information is independently developed by CIMS based on retinol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to CIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, CIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 CIMS. All rights reserved. Powered by CIMSAsia.com
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