3TC-HBV

3TC-HBV

lamivudine

Manufacturer:

GlaxoSmithKline Indonesia
Concise Prescribing Info
Contents
Lamivudine
Indications/Uses
Chronic hepatitis B infection & evidence of hepatitis B viral replication.
Dosage/Direction for Use
Adult 100 mg once daily. Treatment discontinuation may be considered when HBe & HBs antigen seroconversion occurs.
Administration
May be taken with or without food.
Contraindications
Special Precautions
Periodically monitor ALT & bilirubin at least 4 mth for evidence of recurrent hepatitis. Moderate to severe renal impairment. Greater risk from active viral replication in transplantation recipients & patients w/ advanced liver disease. Concurrent immunosuppressive regimens including cancer chemotherapy. Patients co-infected w/ HIV. Follow standard recommended procedures for HBV immunisation in infants. Patients should be advised that therapy has not been proven to reduce risk of HBV transmission. Pregnancy & lactation.
Adverse Reactions
Malaise & fatigue, resp tract infections, headache, abdominal discomfort & pain, nausea & vomiting, diarrhoea. Elevations of ALT. Elevations of CPK. Muscle disorders including myalgia & cramps.
Drug Interactions
Trimethoprim/sulphamethoxazole causes an increase 3TC-HBV exposure by about 40%. May inhibit intracellular phosphorylation of zalcitabine.
MIMS Class
Antivirals
ATC Classification
J05AF05 - lamivudine ; Belongs to the class of nucleoside and nucleotide reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.
Presentation/Packing
Form
3TC-HBV FC tab 100 mg
Packing/Price
28's
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