Iomeprol


Concise Prescribing Info
Indications/Uses
Radiographic contrast media.
Dosage/Direction for Use
Adult : IV/Intra-arterial/Intrathecal As 30.62-81.65 % w/v solution: Dose and strength vary according to the procedure and route. Refer to individual product literature.
Dosage Details
Intra-arterial, Intrathecal, Intravenous
Contrast media, radiographic
Adult: As 30.62 to 81.65 % w/v solution: Dose and strength vary according to the procedure and route. Refer to individual product literature.
Child: Same as adult dose.
Contraindications
Hypersensitivity. Multiple myeloma, Waldenstroem’s paraproteinaemia. Intrathecal concomitant administration with corticosteroid. Severe hepatic and renal impairment.
Special Precautions
Patient with asthma, history of allergy, heart failure, coronary artery disease, diabetes mellitus, hyperthyroidism or goitre, myasthenia gravis, cerebral infarction, acute intracranial haemorrhage, conditions involving blood-brain barrier damage, brain oedema, acute demyelination, intracranial tumours or metastases, history of epilepsy, cerebrovascular disease, acute and chronic alcoholism, drug addiction, phaeochromocytoma, sickle cell disease. Moderate renal and hepatic impairment. Neonates, infants and children. Pregnancy and lactation.
Adverse Reactions
Significant: Myelomatosis or paraproteinaemias, pulmonary oedema, haemodynamic changes, ischaemic ECG changes, arrhythmias, convulsive seizures, exacerbation of myasthenia, neurological complications, vasospasm, cerebral ischaemic phenomena, anxiety, excitement, pain.
Gastrointestinal disorders: Nausea, vomiting, abdominal pain, diarrhoea, taste disturbance.
General disorders and administration site conditions: Injection site pain, chest pain, heat sensation.
Musculoskeletal and connective tissue disorders: Back pain.
Nervous system disorders: Headache, dizziness.
Respiratory, thoracic and mediastinal disorders: Dyspnoea.
Skin and subcutaneous tissue disorders: Erythema, urticaria, pruritus.
Vascular disorders: Flushing, hypertension.
Potentially Fatal: Severe anaphylactoid and CV reactions (e.g. severe hypotension, tachycardia, dyspnoea, cardiac arrest).
Patient Counseling Information
This drug may cause delayed reactions, if affected, do not drive or operate machinery.
MonitoringParameters
Monitor electrolyte fluid balance prior to administration; renal function. Maintain hydration prior and during the procedure.
Overdosage
Symptoms: Life-threatening pulmonary and CV adverse reactions. Management: Symptomatic and supportive treatment.
Drug Interactions
Risk of bronchospasm with β-blockers. Reduced seizure threshold with neuroleptics and antidepressants (e.g. MAO inhibitors, TCA, analeptics, anti-emetics phenothiazines); discontinue for 48 hours before and resume 24 hours after the procedure. Increased risk of lactic acidosis with concomitant use of metformin; discontinue prior to procedure and withhold for 48 hours after the procedure.
Potentially Fatal: Concurrently administered corticosteroids may promote and affect the signs and symptoms of arachnoiditis (intrathecal).
Lab Interference
May interfere with thyroid function tests; bilirubin, proteins, Fe, copper, Ca, phosphate tests.
Action
Description: Iomeprol is a nonionic iodinated contrast medium used in radiographic procedures including myelography, urography, arthrography and computed tomography.
Pharmacokinetics:
Absorption: Completely absorbed from the cerebrospinal fluid (intrathecal).
Excretion: Via urine (50%, as unchanged drug). Terminal elimination half-life: 1.9 hours; 8-11 hours (intrathecal).
Chemical Structure

Click on icon to see table/diagram/image
Storage
Store below 30°C. Protect from light.
ATC Classification
V08AB10 - iomeprol ; Belongs to the class of watersoluble, nephrotropic, low osmolar preparations used as X-ray contrast media.
Disclaimer: This information is independently developed by MIMS based on Iomeprol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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