Inj: Mecobalamin is susceptible to photolysis (can decompose due to light even when in a brown ampoule), then must be used immediately after the package is opened and do not exposed the ampoules to light because exposure to light result in a decrease in the content of the active ingredient.
In intramuscular administration, care should be exercised, as suggested as follows, to avoid adverse effects on tissues or nerves: Repeated injection at the same site should be avoided. Particular care should be exercised when administering this drugs to neonates, premature infants, infants and children.
The course of nerves should be avoided for the site of injection.
If the patient complains of pain or if blood reflux occurs when the syringe needle is stuck, withdraw it immediately and try at a different site.
This drug should not be used over a period of months if there is lack of satisfactory clinical response in patients with megaloblastic anemia or with peripheral neuropathies probably due to vitamin B12 deficiency.