Mepacrine


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Giardiasis 100 mg 3 times/day for 5-7 days. Lupus erythematosus 100 mg once daily for the 1st 1-2 mth. Maintenance: 25-50 mg/day several times a wk. Intrapleural Prophylaxis of pneumothorax Instill 100 mg once daily for 3-4 consecutive days.
Dosage Details
Intrapleural
Prophylaxis of pneumothorax
Adult: As hydrochloride: 100 mg instilled once a day for 3-4 consecutive days.

Oral
Giardiasis
Adult: As hydrochloride: 100 mg tid for 5-7 days.
Child: As hydrochloride: 2 mg/kg tid for 5-7 days. Max dose: 300 mg daily.

Oral
Lupus erythematosus
Adult: As hydrochloride: 100 mg once a day for the first 1-2 mth. Maintenance dose: Reduce to 25-50 mg once a day several times a wk, although occasional management with 100-200 mg once daily may be required.
Child: As hydrochloride: 1-2 mg/kg, up to 100 mg/day. Max dose: 100 mg daily.
Contraindications
Hypersensitivity; psoriasis.
Special Precautions
Elderly, history of psychosis, hepatic disease, porphyria. Pregnancy and lactation.
Adverse Reactions
Dizziness, headache; nausea, vomiting; reversible yellow discolouration of the skin, conjunctiva, urine (on prolonged use); blue-black discolouration of the palate and nails; psychosis, CNS stimulation, convulsions; ocular toxicity chronic dermatoses; rarely, liver toxicity and aplastic anaemia.
Overdosage
Symptoms: Seizures, hypotension,cardiac arrhythmia, cardiovascular collapse. Management: Gastric lavage or induction of emesis. Symptomatic and supportive.
Drug Interactions
May produce disulfiram-type reaction with alcohol. May increase plasma concentrations and toxicity of primaquine.
Action
Description: Mepacrine is a 9-aminoacridine antiprotozoal agent. It is used in the treatment of giardiasis (as an alternative to the nitroimidazoles), treatment of discoid and SC lupus erythematosus, and prophylaxis of pneumothorax (as an sclerosing agent). Its use for nonsurgical sterilisation in some countries is controversial and it was formerly used as an antimalarial agent. One suggested mechanism for its antiparasitic action is binding to DNA thereby inhibiting RNA transcription and translation.
Pharmacokinetics:
Absorption: Absorbed rapidly from GI tract (oral); absorbed rapidly after intrapleural and intrauterine admin. Peak plasma levels after 8-12 hr.
Distribution: Widely distributed in body tissues. Crosses the placenta and distributes in breast milk. Protein-binding: 80-90%.
Excretion: Via urine (<11%); via faeces; small amounts excreted in bile, sweat and saliva.
Storage
Oral:
Store at 15-30°C (59-86°F).
Disclaimer: This information is independently developed by MIMS based on Mepacrine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in