Pyrexin Extra

Pyrexin Extra

tramadol + paracetamol

Manufacturer:

Meprofarm

Marketer:

Meprofarm
Concise Prescribing Info
Contents
Paracetamol 325 mg, tramadol HCl 37.5 mg
Indications/Uses
Dosage/Direction for Use
Adult & childn >16 yr Max single dose: 1-2 tab every 4-6 hr as needed for pain relief. Max daily dose: 8 tab.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to paracetamol, tramadol or opioids. Situations where opioids are contraindicated excluding acute poisoning cases w/ alcohol, hypnotics, narcotics, anlagesics that work on CNS or psychotropic drugs.
Special Precautions
Risk of seizure in co-administration w/ SSRIs, TCAs, MAOIs, other opioids, neuroleptics & other drugs that reduce seizure threshold. Anaphylactoid reaction & resp depression. Increased intracranial pressure or head injury. Alcohol. Concomitant use w/ other paracetamol-containing medicine may increase toxicity. Discontinue treatment gradually to avoid w/drawal syndrome. Monitor prothrombin time during concomitant use w/ warfarin-like compd. Hepatic impairment. Pregnancy & lactation. Elderly.
Adverse Reactions
Nausea, dizziness, drowsiness; asthenia, fatigue, blushing; CNS & peripheral nervous system disorder (headache, tremor); GI disorder; psychiatric disorders; pruritus, rash, excessive sweating; mental disorder; anemia; dyspnea; albuminuria, urinary disorders, oliguria, urinary retention; vision disorder; w/drawal syndrome.
Drug Interactions
Increased tramadol metabolism w/ carbamazepine. Increased tramadol plasma conc w/ quinidine. Increased INR w/ warfarin-like compd. Inhibition of tramadol metabolism w/ CYP2D6 inhibitors eg, fluoxetine, paroxetine, amitriptyline.
MIMS Class
ATC Classification
N02AJ13 - tramadol and paracetamol ; Belongs to the class of opioids in combination with other non-opioid analgesics. Used to relieve pain.
Presentation/Packing
Form
Pyrexin Extra FC caplet
Packing/Price
3 × 10's (Rp135,000/boks)
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