AdultGastric, duonenal ulcer, reflux esophagitis 150 mg twice daily, in the morning & night, or 300 mg once daily before bedtime for 4-8 wk. Maintenance: 150 mg daily before bedtime. Prophylaxis of peptic ulcer 150 mg twice daily. Zollinger-Ellison’s syndrome Initially 150 mg 3 times daily. Childn 8-18 yr Doses up to 150 mg 1-2 times daily.