Adempas

Adempas

riociguat

Manufacturer:

Bayer

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Riociguat
Indications/Uses
Chronic thromboembolic pulmonary HTN, pulmonary arterial HTN.
Dosage/Direction for Use
Adult Initially, 1 mg tds for 2 wk, may be increased by 0.5-mg tds every 2 wk to max: 7.5 mg daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Co-administration w/ PDE5 inhibitors, nitrates or nitric oxide donors. Patients w/ systolic BP <95 mmHg; pulmonary HTN associated w/ idiopathic interstitial pneumonias. Severe hepatic impairment. Pregnancy.
Special Precautions
Pulmonary veno-occlusive disease. Hypotension. Smokers. Monitor patients receiving anticoagulation therapy. Concomitant use w/ azole antimycotics (eg, ketoconazole, itraconazole) or  HIV PIs (eg, ritonavir). Not recommended in patients w/ CrCl <30 mL/min or on dialysis. Mild & moderate renal & moderate hepatic impairment. Childn & adolescents <18 yr.
Adverse Reactions
Dizziness, headache; dyspepsia, diarrhoea, nausea, vomiting; peripheral oedema. Gastroenteritis; anemia; palpitations; hypotension; haemoptysis, epistaxis, nasal congestion; gastritis, GERD, dysphagia, GI & abdominal pains, constipation, abdominal distension.
Drug Interactions
Increased exposure w/ CYP450, UGT1A1 & 1A9, P-glycoprotein/BCRP eg, ketoconazole, itraconazole & HIV PIs eg, ritonavir. Potentiated blood lowering effect of SL nitroglycerin. Additive systemic BP lowering effect w/ sildenafil or vardenafil. Caution w/ cyclosporine A. Lowered oral bioavailability w/ drugs that increase upper GI pH. Reduced mean AUC & Cmax by antacids eg, Al & Mg hydroxide. Decreased steady-state plasma conc by bosentan & strong CYP3A4 inducers eg, phenytoin, carbamazepine, phenobarb or St. John's wort.
ATC Classification
C02KX05 - riociguat ; Belongs to the class of other antihypertensives. Used in the treatment of pulmonary arterial hypertension.
Presentation/Packing
Form
Adempas FC tab 2.5 mg
Packing/Price
42's
Form
Adempas FC tab 1 mg
Packing/Price
42's
Form
Adempas FC tab 1.5 mg
Packing/Price
42's
Form
Adempas FC tab 2 mg
Packing/Price
42's
Form
Adempas FC tab 0.5 mg
Packing/Price
42's
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