Ajmaline


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : IV Supraventricular and ventricular arrhythmias; Diagnosis of Wolff-Parkinson-White syndrome 50 mg over at least 5 mins.
Dosage Details
Intravenous
Differential diagnosis of Wolff-Parkinson-White syndrome, Supraventricular arrhythmias, Ventricular arrhythmias
Adult: 50 mg via IV inj over at least 5 minutes. May also be given by IV infusion, IM inj and oral route.
Contraindications
Digitalis overdosage; complete heart block; lactation; hypersensitivity.
Special Precautions
Incomplete heart block, uncompensated heart failure; myasthenia gravis; elderly; pregnancy. Initiate therapy with extreme caution during acute infections or fever.
Adverse Reactions
Heart block; cardiac arrhythmias; eye twitching; convulsions; resp depression; hepatotoxicity; agranulocytosis.
Potentially Fatal: Coma.
Drug Interactions
Quinidine.
Action
Description: Ajmaline directly interferes with depolarization of the cell membrane by blocking the fast inward current of Na into cardiac cells. It slows the rate of change of the depolarization phase of the action potential, moderately prolong the PR, QRS and QT intervals on ECG monitoring. It also has local anesth properties.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Ajmaline from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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