Y.S.P. Industries


Y.S.P. Industries
Concise Prescribing Info
Donepezil HCl
Mild, moderate & severe Alzheimer's dementia.
Dosage/Direction for Use
Adult & elderly Mild to moderate Alzheimer's disease 5 mg once daily in the evening for at least 1 mth. May be increased to max: 10 mg once daily following 4-6 wk of clinical assessment. Severe Alzheimer's disease 10 mg once daily.
May be taken with or without food: Take at bedtime. Place tab on the tongue & allow to disintegrate before swallowing w/ or w/o water.
Hypersensitivity to donepezil HCl, piperidine derivatives.
Special Precautions
Neuroleptic malignant syndrome. Sick sinus syndrome or other supraventricular cardiac conduction conditions eg, SA or AV block; syncope & seizures; bladder outflow obstruction. History of ulcer disease, asthma or obstructive pulmonary disease. May exacerbate or induce extrapyramidal symptoms. Concomitant use w/ succinylcholine-type anesth; NSAIDs. Avoid concomitant use w/ other inhibitors of acetylcholinesterase agonists or cholinergic system antagonists. May affect ability to drive & use machines. Severe hepatic impairment. Pregnancy & lactation. Not recommended in childn.
Adverse Reactions
Diarrhoea, nausea; headache. Common cold; anorexia; hallucinations, agitations, aggressive behavior, abnormal dreams & nightmares; syncope, dizziness, insomnia; vomiting, abdominal disturbance; rash, pruritus; muscle cramps; urinary incontinence; fatigue, pain; accident.
Drug Interactions
Interfered w/ medications having anticholinergic activity. Synergistic activity w/ succinylcholine, other neuromuscular blockers or cholinergic agonists or β-blockers. Prolonged neuromuscular blockade w/ succinylcholine. Reduced levels by enzyme inducers eg, rifampicin, phenytoin, carbamazepine & alcohol. Decreased cholinesterase inhibitor efficacy w/ oxybutynin, tolterodine. Increased ramelteon exposure. Cholinergic adverse effects w/ bethanechol. Increased bioavailability w/ quinidine, ketoconazole. Inhibited metabolism by itraconazole, erythromycin & CYP2D6 inhibitors eg, fluoxetine.
ATC Classification
N06DA02 - donepezil ; Belongs to the class of anticholinesterases. Used in the management of dementia.
Arizil orodispersible tab 10 mg
12 × 10's;3 × 10's;50 × 10's
Arizil orodispersible tab 5 mg
12 × 10's;3 × 10's;50 × 10's
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