Cefmetazole


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : IV/IM Treatment and prophylaxis of anaerobic and mixed bacterial infections; Gonorrhoea 0.5-1 g 12 hrly. Severe infections: 3-4 g/day, given in divided doses 6-8 hrly.
Dosage Details
Parenteral
Anaerobic bacterial infections, Gonorrhoea, Mixed bacterial infections, Prophylaxis of anaerobic bacterial infections, Prophylaxis of mixed bacterial infections
Adult: 0.5-1 g every 12 hr via IM inj or slow IV inj over 3-5 minutes. Severe infections: 3-4 g daily, given in divided doses every 6-8 hr. Dose can also be given via IV infusion over 10-60 minutes.
Renal Impairment
Interval between doses: 12, 16, or 24 hr in patients with mild, moderate or severe renal impairment, respectively. Patients with virtually no renal function: dose may be given every 48 hr after hemodialysis.
Contraindications
Hypersensitivity to cephalosporins.
Special Precautions
History of allergy; porphyria; renal impairment. Monitor renal and haematological states during prolonged and high-dose thearapy. Lactation.
Adverse Reactions
Hypersensitivity reactions; nephrotoxicity; neutropenia; thrombocytopenia; agranulocytosis; bleeding complications related to hypoprothrombinaemia or platelet dysfunction; GI effects; CNS toxicity; superinfection; pain at Inj site (IM); thrombophloebitis (IV infusion); hepatitis; cholestatic jaundice.
Potentially Fatal: Pseudomembranous colitis.
Drug Interactions
Disulfiram-like reaction with alcohol; may enhance hypoprothrombinemic response to anticoagulants; renal clearance reduced by probenecid.
Lab Interference
Transient increases in liver enzyme values; false-positive reactions for glucose using copper-reduction reactions; positive direct Coombs' test. May produce falsely high values in Jaffe method of measuring creatinine concentration.
Action
Description: Cefmetazole has similar spectrum of activity to that of cefoxitin, and includes Bacteroides fragilis.
Pharmacokinetics:
Distribution: 65-85% bound to plasma proteins.
Excretion: Plasma half-life: 1.1-1.5 hr. Prolonged in renally impaired patients. Excreted unchanged in the urine.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Cefmetazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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