Chlorprothixene


Concise Prescribing Info
Indications/Uses
Psychoses.
Dosage/Direction for Use
Adult : PO 15-50 mg 3-4 times/day, up to ≥600 mg/day in severe conditions. IM 25-100 mg up to 4 times/day.
Dosage Details
Intramuscular
Psychoses
Adult: 25-100 mg up to 4 times daily.
Elderly: Dose reduction may be needed.

Oral
Psychoses
Adult: 15-50 mg 3-4 times daily increased according to response for up to 600 mg or more daily in severe or resistant conditions.
Elderly: Dose reduction may be needed.
Administration
May be taken with or without food. Take w/ meals or milk if GI upset occurs.
Contraindications
Coma; CNS depression; pheochromocytoma.
Special Precautions
Hepatic or renal impairment; history of jaundice; CV disease; angle-closure glaucoma; diabetes mellitus; hyperthyroidism; Parkinson's disease; epilepsy, depression, myasthenia gravis; prostatic hypertrophy; severe respiratory disease; blood dyscrasias. May precipitate coma, affect driving; elderly and children. Pregnancy and lactation
Adverse Reactions
Dry mouth, constipation, urinary retention, mydriasis; agitation, insomnia, depression, convulsions, nasal congestion, tachycardia, postural hypotension, blurred vision, inhibition of ejaculation; urticaria, exfoliative dermatitis; agranulocytosis; extrapyramidal dysfunction; altered endocrine and metabolic functions.
Drug Interactions
ACE inhibitors, α-blockers, amantadine, general anaesthetics, angiotensin-II receptor antagonists, antiarrhythmics, tricyclic antidepressants, anxiolytics and hypnotics, apomorphine, artemether with lumefantrine, barbiturates, bromocriptine, cabergoline, calcium-channel blockers, carbamazepine, cimetidine, ethosuximide, levodopa, lisuride, memantine, methyldopa, metoclopramide, opioid analgesics, oxcarbazepine, pergolide, phenytoin, pramipexole, primidone, ritonavir, ropinirole, sibutramine, sympathomimetics, terfenadine, tetrabenazine, tramadol and valproate. Alcohol.
Lab Interference
Immunologic urine pregnancy test; urine bilirubin test; serum uric acid concentrations.
Action
Description: Chlorprothixene blocks postsynaptic dopamine receptors in the brain and also produces an α-adrenergic blocking effect thus depressing the release of hypothalamic and hypophyseal hormones. Prolactin levels are increased due to blockade of prolactin inhibitory factor. It also possesses antiemetic and sedative properties.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Chlorprothixene from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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