Diloxanide


Concise Prescribing Info
Indications/Uses
Intestinal amoebiasis.
Dosage/Direction for Use
Adult : PO 500 mg 3 times/day for 10 days. May repeat course if needed.
Dosage Details
Oral
Intestinal amoebiasis
Adult: 500 mg tid for 10 days. May repeat course if needed.
Child: >25 kg: 20 mg/kg daily in 3 divided doses for 10 days, repeated if necessary.
Special Precautions
Pregnancy and lactation.
Adverse Reactions
Flatulence, anorexia, nausea, vomiting, pruritus, urticaria.
Action
Description: Diloxanide is a luminal amoebicide which is hydrolysed in the gut, thus releasing the free diloxanide which acts as an amoebicide. It is given alone in asymptomatic cyst passers. For patients with active amoebic infections, it can be administered with a 5-nitroimidazole e.g. metronidazole or tinidazole.
Pharmacokinetics:
Absorption: Absorbed from the GI tract (oral).
Metabolism: Rapidly hydrolysed prior to absorption.
Excretion: Via faeces (<10% of dose).
Storage
Store at 25°C.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Diloxanide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in