Dimethindene


Concise Prescribing Info
Indications/Uses
Allergic conditions.
Dosage/Direction for Use
Adult : PO 1-2 mg 3 times/day. Topical As 0.1% gel/lotion: Use as directed.
Dosage Details
Oral
Allergic conditions
Adult: As maleate: 1-2 mg tid.

Topical/Cutaneous
Pruritic skin disorders
Adult: As 0.1% gel/lotion: Use as directed.
Contraindications
Neonates, infants, urinary retention, paralytic ileus.
Special Precautions
Elderly, closed-angle glaucoma, benign prostatic hyperplasia, driving, epilepsy, GI tract obstruction. Pregnancy and lactation.
Adverse Reactions
CNS depression, paradoxical CNS excitation, dryness of mouth, thickened resp mucus, urinary retention, constipation, tachycardia and arrhythmias, blurring of vision, GI upsets, blood dyscrasias. Topical application: Sensitisation.
Drug Interactions
Masks ototoxicity produced by aminoglycosides and antibiotics. Potentiate CNS depressant actions of alcohol, barbiturates, sedatives, opioid analgesics and neuroleptics. May block the effects of betahistine. QT prolongation may occur when used with mefloquine. May cause increased sedative effects when used with thalidomide.
Potentially Fatal: Additive antimuscarinic action with MAOIs, atropine and TCAs.
Action
Description: Dimethindene is an alkylamine derivative. It is mildy sedative and have mast-cell stabilising properties. It is also a potent H1-antagonist and possesses significant sedative actions. May cause paradoxical stimulation of CNS esp in children.
Disclaimer: This information is independently developed by MIMS based on Dimethindene from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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