rocuronium bromide


Merck Sharp & Dohme


Zuellig Pharma
Concise Prescribing Info
Rocuronium Br
Adjunct to general anesth to facilitate endotracheal intubation, to provide skeletal muscle relaxation during surgery & to facilitate mechanical ventilation in adults, childn & infants from 1 mth. Adjunct in ICU to facilitate mechanical ventilation as part of Rapid Sequence Induction in adults.
Dosage/Direction for Use
Tracheal intubation: 0.6 mg/kg. Maintenance: 0.15 mg/kg. Long-term inhalation anaesth: Reduce to 0.075-0.1 mg/kg. Maintenance doses should best be given when twitch height has recovered to 25% of control twitch height. Continuous infusion: 0.6 mg/kg loading dose. Geriatric & patient w/ hepatic, biliary &/or renal failure 0.6 mg/kg. Maintenance: 0.075-0.1 mg/kg.
Special Precautions
Anaphylaxis. CV disease, oedematous state; neuromuscular disease, poliomyelitis; hypothermia; obesity; burns; hypokalaemia, hypermagnesemia, hypocalcemia, hypoproteinemia, dehydration, acidosis, hypercapnia, cachexia. Residual curarization. Long-term use in ICU setting. Concomitant use w/ corticosteroids; suxamethonium. May affect ability to drive & use machines. Hepatic &/or biliary tract disease; renal failure. Pregnancy & lactation. Elderly.
Adverse Reactions
Anaphylactic & anaphylactoid reactions. Inj site pain/reaction, changes in vital signs, prolonged neuromuscular block.
Drug Interactions
Increased effects w/ halogenated volatile anesth, suxamethonium, corticosteroids; aminoglycoside, lincosamide, polypeptide & acylamino-penicillin antibiotics; diuretics, quinidine, quinine, Mg salts, Ca-channel blockers, lithium salts, local anesth (lidocaine IV, bupivacaine epidural), acute administration of phenytoin or β-blockers. Decreased effects w/ phenytoin or carbamazepine; PIs eg, gabexate, ulinastatin. Potentiated or attenuated neuromuscular blocking effects w/ other non-depolarizing neuromuscular blockers, suxamethonium. Quicker onset of action of lidocaine.
ATC Classification
M03AC09 - rocuronium bromide ; Belongs to the class of other quaternary ammonium-containing agents used as peripherally-acting muscle relaxants.
Esmeron soln for inj (vial) 50 mg/5 mL
10 × 1's
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