insulin human, isophane


Novo Nordisk


Zuellig Pharma
Concise Prescribing Info
Isophane insulin, rDNA
Dosage/Direction for Use
SC Individualized dosage ranging from 0.3-1 IU/kg daily.
Special Precautions
Not to administered IV & not to be used in insulin pumps. Inadequate dosing or discontinuation of treatment especially in type 1 DM. Concomitant illness, infections & feverish conditions. Diseases affecting adrenal, pituitary or thyroid gland. Physical activity or diet changes. Diabetic ketoacidosis, hypoglycaemia, longstanding diabetes. Transferring to another type of insulin. Lipodystrophy, inj site reactions. Combination w/ thiazolidinediones in CHF patients. May affect ability to drive & use machines. Renal & hepatic diseases. Intensified blood glucose control & monitoring during pregnancy. Dosage or diet adjustment during lactation.
Adverse Reactions
Hypoglycaemia. Urticaria, rash; diabetic retinopathy; lipodystrophy; inj site reactions; oedema.
Drug Interactions
Reduced insulin requirement w/ oral antidiabetics, MAOIs, non-selective β-blockers, ACE inhibitors, salicylates, anabolic steroids, sulphonamides. Increased insulin requirement w/ OCs, thiazides, glucocorticoids, thyroid hormones, sympathomimetics, growth hormone, danazol. Masked hypoglycaemia symptoms & delayed recovery from hypoglycaemia by β-blockers. Increased or decreased insulin requirement w/ octreotide/lanreotide. Intensified or reduced insulin hypoglycaemic effect by alcohol.
MIMS Class
Insulin Preparations
ATC Classification
A10AC01 - insulin (human) ; Belongs to the class of intermediate-acting insulins and analogues. Used in the treatment of diabetes.
Insulatard FlexPen 100 IU/mL
3 mL x 5 × 1's
Insulatard penfill for inj 100 IU/mL
3 mL x 5 × 1's
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