Itrazol

Itrazol

itraconazole

Manufacturer:

Noripharma

Distributor:

Pahang Pharmacy
Concise Prescribing Info
Contents
Itraconazole
Indications/Uses
Vulvovag candidosis, pityriasis versicolor, dermatomycosis, oral candidosis, onychomycosis caused by dermatophytes/yeasts, systemic aspergillosis & candidosis, cryptococcosis (including cryptococcal meningitis), histoplasmosis, sporotrichosis, paracoccidioidomycosis, blastomycosis & other rarely occurring systemic or topical mycoses.
Dosage/Direction for Use
Vulvovag candidosis 2 cap bd for 1 day or 2 cap once daily for 3 daily. Pityriasis versicolor 2 cap once daily for 7 days. Tinea pedis & manuum 2 cap bd for 7 days or 1 cap once daily for 30 days. Oropharyngeal candidosis 1 cap once daily for 15 days. Tinea corporis & cruris 2 cap once daily for 7 days or 1 cap once daily for 15 days. Fingernail onychomycosis 2 cap bd for 1 wk/mth for 2 mth. Toenail onychomycosis 2 cap bd for 1 wk/mth for 3 mth. Aspergillosis 200 mg once daily for 2-5 mth, may be increased to 200 mg bd. Candidosis 100-200 mg once daily for 3 wk-7 mth, may be increased to 200 mg bd. Non-meningeal cryptococcosis 200 mg once daily for 2 mth-1 yr. Maintenance (meningeal cases): 200 mg once daily. Cryptococcal meningitis 200 mg bd for 2 mth-1 yr. Maintenance (meningeal cases): 200 mg once daily. Histoplasmosis 200 mg once or bd for 8 mth. Sporotrichosis 100 mg once daily for 3 mth. Paracoccidioidomycosis 100 mg once daily for 6 mth. Chromomycosis 100-200 mg once daily for 6 mth. Blastomycosis 100 mg once daily-200 mg bd for 6 mth.
Administration
Should be taken with food: Take immediately after a full meal.
Contraindications
Hypersensitivity to other azole antifungals. Onychomycosis in patients w/ evidence of cardiac dysfunction eg, CHF. Concomitant use w/ cisapride, pimozide or quinidine. Pregnancy.
Special Precautions
Discontinue use if neuropathy & abnormalities occur. Decreased gastric acidity may impair absorption. Administer acid-neutralising medicines at least 2 hr after. Administer w/ cola beverage in achlorhydria eg, certain AIDS patients & patients on acid-suppressing medicine ie, H2-receptor antagonists & proton-pump inhibitors. Monitor liver function in continuous treatment >1 mth. Cirrhotic patients, renal insufficiency. Women of childbearing potential should use effective contraception. Lactation. Not to be used in childn <12 yr.
Adverse Reactions
Dyspepsia, nausea, abdominal pain, constipation; hypokalaemia, oedema, hepatitis, hair loss.
Drug Interactions
Increased metabolism & lowered plasma conc by rifampicin, carbamazepine, INH, phenytoin. Increased bioavailability by clarithromycin, indinavir, ritonavir. Inhibit metabolism of terfenadine, astemizole, cisapride, oral midazolam, triazolam, vincristine, lovastatin, simvastatin. Prolonged sedative effect of IV midazolam. Increased plasma levels of cyclosporin A, digoxin, tolbutamide, chlorpropamide, glyburide, glipizide. Enhanced effect of nicoumalone, warfarin. Monitor for side effects w/ dihydropyridine Ca-channel blockers & quinidine.
MIMS Class
ATC Classification
J02AC02 - itraconazole ; Belongs to the class of triazole derivatives. Used in the systemic treatment of mycotic infections.
Presentation/Packing
Form
Itrazol cap 100 mg
Packing/Price
7 × 4's
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