Tab Adult & childn >12 yr, >50 kg Recommended dose: 400 mg once daily. Uncomplicated multidrug-resistant typhoid fever 15-20 mg/kg/24 hr for 7-14 days. Quinolone-resistant typhoid fever 20 mg/kg/24 hr for 7-14 days. Uncomplicated cervical/urethral gonococcal infections 400 mg as single dose. Strep pyogenes infections At least 10 days. Oral susp Childn Recommended dose: 8 mg/kg daily as single dose or 4 mg/kg in 2 divided doses every 12 hr. Childn 37.5 kg 15 mL daily, 31.25 kg 12.5 mL daily, 25 kg 10 mL daily, 18.75 kg 7.5 mL daily, 12.5 kg 5 mL daily, 6.25 kg 2.5 mL daily. Uncomplicated multidrug- & quinolone-resistant typhoid fever 20 mg/kg/24 hr in divided doses bd for 7 days. Strep pyogenes infections At least 10 days. CrCl >60 mL/min 400 mg daily, 21-60 mL/min 300 mg daily, <20 mL/min 200 mg daily.
Hypersensitivity to penicillins & cephalosporins. Cross hypersensitivity among β-lactam antibiotics. Overgrowth of resistant organisms; superinfection; pseudomembranous colitis; history of GI disease. Renal impairment; on dialysis. Pregnancy & lactation. Childn <6 mth.
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