Josamycin


Concise Prescribing Info
Indications/Uses
Susceptible infections.
Dosage/Direction for Use
Adult : PO 1-2 g/day in 2 or more divided doses.
Dosage Details
Oral
Susceptible infections
Adult: 1-2 g daily in 2 or more divided doses.
Contraindications
Hypersensitivity.
Special Precautions
Hepatic or renal impairment; prolongation of QT interval; porphyria; pregnancy; lactation; myasthenia gravis.
Adverse Reactions
GI disturbances; hypersensitivity reactions; reversible hearing loss; pancreatitis; cholestatic jaundice; CV effects; myasthenia-like syndrome; Stevens-Johnson syndrome; toxic epidermal necrolysis.
Drug Interactions
Reduces efficacy of oral contraceptives. Increases concentrations and/or toxicity of: benzodiazepines, bromocriptine, ciclosporin, digoxin, ergot and derivatives, amitriptyline.
Potentially Fatal: QT prolonging drugs
Action
Description: Josamycin binds reversibly to 50s ribosomal subunit causing blockage of transpeptidation/translocation reactions, inhibition of protein synthesis and thus inhibition of cell growth. Spectrum of activity includes many gm+ve and some gm-ve bacteria as well as mycoplasmas, spirochetes, chlamydias and rickettsias. Josamycin is more active than erythromycin against some strains of anaerobic species eg, Bacteroides fragilis.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Josamycin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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