Maxitrol

Maxitrol

dexamethasone + neomycin + polymyxin b

Manufacturer:

Novartis

Distributor:

DKSH
Concise Prescribing Info
Contents
Neomycin sulfate 3,500 IU, polymyxin B sulphate 6,000 IU, dexamethasone 1 mg
Indications/Uses
Ocular inflammation when concurrent use of antimicrobial is judged necessary.
Dosage/Direction for Use
Ophth susp Severe disease 1-2 drops hrly into conjunctival sac. Ophth oint Apply small amount into conjunctival sac tds-qds, may be used adjunctively w/ drops at bedtime.
Contraindications
Hypersensitivity. Herpes simplex keratitis, vaccinia, varicella & other viral cornea & conjunctiva infections. Fungal diseases of ocular structures or untreated parasitic eye infections. Mycobacterial ocular infections.
Special Precautions
Discontinue use if hypersensitivity reactions, fungal infection or superinfection occurs. Cross-hypersensitivity to other aminoglycosides. Predisposed patients eg, diabetes. Overgrowth of nonsusceptible organisms. Masks clinical signs of infection. Skin sensitization. Diseases causing thinning of cornea & sclera. Remove contact lens prior to application & wait 15 min before reinsertion. Avoid application to open wounds or damaged skin. Prolonged use. Concomitant use of topical NSAIDs & steroids, systemic aminoglycosides, polymyxin B. Avoid use w/ CYP3A4 inhibitors eg, ritonavir, cobicistat. May affect ability to drive & use machines. Not recommended during pregnancy. Lactation. Not to be used in ped. Ophth susp: Eye irritation due to benzalkonium Cl. Ophth oint: Delayed allergic reactions w/ methyl- & propylparahydroxybenzoate; local skin reactions due to wool fat.
Adverse Reactions
Hypersensitivity, headache, Stevens-Johnson syndrome. Ulcerative keratitis, blurred vision, photophobia, mydriasis, eyelid ptosis, eye pain & swelling, foreign body sensation in eyes, ocular hyperaemia, decreased lacrimation.
Drug Interactions
Increased potential for corneal healing problems w/ topical NSAIDs. Increased systemic exposure w/ CYP3A4 inhibitors eg, ritonavir, cobicistat.
ATC Classification
S01CA01 - dexamethasone and antiinfectives ; Belongs to the class of corticosteroids in combination with antiinfectives. Used in the treatment of eye diseases.
Presentation/Packing
Form
Maxitrol ophth susp
Packing/Price
5 mL x 1's
Form
Maxitrol ophth oint
Packing/Price
3.5 g x 1's
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