Discontinue use if hypersensitivity reactions, fungal infection or superinfection occurs. Cross-hypersensitivity to other aminoglycosides. Predisposed patients eg, diabetes. Overgrowth of nonsusceptible organisms. Masks clinical signs of infection. Skin sensitization. Diseases causing thinning of cornea & sclera. Remove contact lens prior to application & wait 15 min before reinsertion. Avoid application to open wounds or damaged skin. Prolonged use. Concomitant use of topical NSAIDs & steroids, systemic aminoglycosides, polymyxin B. Avoid use w/ CYP3A4 inhibitors eg, ritonavir, cobicistat. May affect ability to drive & use machines. Not recommended during pregnancy. Lactation. Not to be used in ped. Ophth susp: Eye irritation due to benzalkonium Cl. Ophth oint: Delayed allergic reactions w/ methyl- & propylparahydroxybenzoate; local skin reactions due to wool fat.