Astellas Pharma


Concise Prescribing Info
Micafungin Na
Invasive candidiasis in childn & adults. Oesophageal candidiasis in adults, adolescents ≥16 yr & elderly patients for whom IV therapy is appropriate. Prophylaxis of Candida infection in childn & adult patients undergoing allogeneic haematopoietic stem cell transplantation or patients who are expected to have neutropenia (absolute neutrophil count <500 cells/microliter) for ≥10 days.
Dosage/Direction for Use
Invasive candidiasis Adult, adolescent, childn ≥4 mth & elderly >40 kg 100 mg daily, may be increased to 200 mg daily, ≤40 kg 2 mg/kg daily, may be increased to 4 mg/kg daily. Childn including neonate <4 mth 4-10 mg/kg daily. Duration: Min of 14 days & continued for at least 1 wk after 2 sequential negative blood cultures have been obtained & after resolution of infection. Oesophageal candidiasis Adult, adolescent ≥16 yr & elderly >40 kg 150 mg daily, ≤40 kg 3 mg/kg daily. Duration: At least 1 wk. Prophylaxis of Candida infection Adult, adolescent, childn ≥4 mth & elderly >40 kg 50 mg daily, ≤40 kg 1 mg/kg daily. Childn including neonate <4 mth 2 mg/kg daily. Duration: At least 1 wk after neutrophil recovery.
Hypersensitivity to micafungin or other echinocandins.
Special Precautions
Discontinue use if anaphylactic/anaphylactoid reactions including shock occur; lesions progress. Monitor closely if rash develops; evidence of worsening haemolysis including acute intravascular haemolysis or haemolytic anaemia. Concomitant therapy including hepatotoxic &/or genotoxic properties. Severe hepatic impairment or chronic liver diseases representing preneoplastic conditions eg, advanced liver fibrosis, cirrhosis, viral hepatitis, neonatal liver disease or congenital enzyme defects. May affect male fertility. Pregnancy & lactation. Paed <2 yr.
Adverse Reactions
Coagulopathy, febrile neutropenia, haemolysis, haemolytic anemia, pancytopenia, thrombotic thrombocytopenic purpura; arrhythmia, atrial fibrillation, cardiac arrest, cyanosis, hypotension, MI, tachycardia; upper abdominal pain, dyspepsia; inj site thrombosis; hepatocellular damage, hepatomegaly, jaundice, hepatic failure; infection, pneumonia, sepsis; acidosis, anorexia, hyponatraemia; arthralgia; convulsions, encephalopathy, intracranial haemorrhage; delirium; anuria, haemoglobinuria, oliguria, acute renal failure, renal tubular necrosis; apnoea, dyspnoea, hypoxia, pulmonary embolism; erythema multiforme, skin necrosis, urticaria; DVT, HTN.
Drug Interactions
Increased AUC of sirolimus. Increased AUC & Cmax of nifedipine, itraconazole.
MIMS Class
ATC Classification
J02AX05 - micafungin ; Belongs to the class of other systemic antimycotics.
Mycamine powd for soln for infusion (single-use vial) 50 mg
10 × 1's;1's
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