Pharmaniaga Simvastatin

Pharmaniaga Simvastatin

simvastatin

Manufacturer:

Pharmaniaga Manufacturing Berhad

Distributor:

Pharmaniaga Logistics
Concise Prescribing Info
Contents
Simvastatin
Indications/Uses
In CHD, to reduce risk of death, coronary death & non-fatal MI, reduce risk for undergoing myocardial revascularisation procedures & slow progression of coronary atherosclerosis, reduce development of new lesions & new total occlusions. Adjunct to diet in patients w/ primary hypercholesterolaemia, heterozygous familial hypercholesterolaemia or mixed hyperlipidaemia when response to diet & other non-pharmacological measures is inadequate.
Dosage/Direction for Use
CHD 20 mg nightly. Max: 80 mg daily given as single evening dose. Hyperlipidaemia 20 mg nightly.
Administration
May be taken with or without food: Avoid excessive consumption (>1 L daily) of grapefruit juice.
Contraindications
Active liver disease, unexplained persistent elevation of serum transaminases, porphyria. Pregnancy & lactation.
Special Precautions
History of liver disease, high alcohol intake. Perform baseline & regular liver function test. Discontinue if serum transaminase conc >3 times upper limit of normal. Avoid concomitant use w/ fibrates.
Adverse Reactions
GI disturbances, asthenia, headache, altered liver function tests, rash, pruritus, alopecia, dizziness, muscle cramps, myalgia, pancreatitis, paraesthesia, peripheral neuropathy.
Drug Interactions
Immunosuppressants, gemfibrozil, lipid-lowering doses of nicotinic acid, macrolides, cholestyramine, colestipol, coumarin anticoagulants, azole antifungals, HIV PIs, nefazodone.
ATC Classification
C10AA01 - simvastatin ; Belongs to the class of HMG CoA reductase inhibitors. Used in the treatment of hyperlipidemia.
Presentation/Packing
Form
Pharmaniaga Simvastatin FC tab 40 mg
Packing/Price
12 × 10's;3 × 10's
Form
Pharmaniaga Simvastatin FC tab 20 mg
Packing/Price
12 × 10's;3 × 10's
Form
Pharmaniaga Simvastatin FC tab 10 mg
Packing/Price
3 × 10's
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