Generic Medicine Info
Indications and Dosage
Paget's disease of bone
Adult: As 2nd or 3rd line of treatment: 25 mcg/kg/day by slow infusion for 15 doses followed by 1500 mcg wkly for 2 mth, then every 2 wk for 6 wk.

Hypercalcaemia and hypercalciuria associated with malignancy
Adult: 25 mcg/kg by slow infusion over 4-6 hr. May be repeated several times at intervals of 24-72 hr.
Pregnancy and lactation. Hypersensitivity.
Special Precautions
Impaired hepatic or renal function. Extravasation. Monitor CBC and electrolytes before each treatment; blood cell counts, coagulation time, hepatic and renal function frequently during treatment and several days after. Patients with coagulopathy.
Adverse Reactions
Dose-related bleeding syndrome, manifested initially as epistaxis. GI effects, metallic taste, mild stomatitis; fever, malaise, drowsiness, lethargy, weakness, headache, depression; skin rashes, facial flushing; reduced serum concentrations of calcium, phosphorus and potassium; reversible renal or hepatic impariment; transient elevated hepatic enzymes; extravasation may cause local irritation, cellulitis and phloebitis.
Potentially Fatal: Epitaxis progressing to haematemesis and fatal haemorrhage. Severe thrombocytopaenia due to bone marrow depression.
Drug Interactions
Admixture with trace element solutions. Chelates divalent cations eg iron.
Mechanism of Action: Plicamycin, a highly toxic antibiotic with antineoplastic and hypocalcaemic properties, is cell-cycle phase-nonspecific that binds to DNA in the presence of divalent cations and inhibits synthesis of RNA. Its hypocalcaemic activity is due to blocking PTH action on osteoclasts.
Store at 2-8°C.
MIMS Class
Cytotoxic Chemotherapy
Disclaimer: This information is independently developed by MIMS based on Plicamycin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by
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