Silver nitrate


Concise Prescribing Info
Indications/Uses
As an antiseptic agent.
Dosage/Direction for Use
Adult : Topical As 0.5% soln: Apply as directed.
Dosage Details
Topical/Cutaneous
Prophylaxis of gonococcal ophthalmia neonatorum
Child: Neonate: As a 1% solution: To be applied after cleansing of the neonate's eyes immediately after birth.

Topical/Cutaneous
Antiseptic agent
Adult: As a 0.5% solution: May be applied to severe burns to reduce risk of infection.
Contraindications
Hypersensitivity. Applicator sticks not for ophthalmic use.
Special Precautions
Prolonged use may result to skin discolouration. Protect surrounding skin and avoid broken skin. Not suitable for application to face, ano-genital region or large areas.
Adverse Reactions
Pain in the mouth, sialorrhoea, diarrhoea, vomiting, coma and convulsions. Argyria (chronic use); methaemoglobinaemia; electrolyte disturbances. Short-term mild conjunctivitis in infants which may lead to blindness if use repeatedly or with high concentrations.
Action
Description: Silver nitrate inhibits growth of both gram-positive and gram-negative bacteria by precipitating bacterial protein through the release of liberated silver ions. It also forms an eschar by coagulation of cellular proteins.
Pharmacokinetics:
Absorption: Minimal GI and cutaneous absorption because of the readiness of silver ions to combine with protein.
Storage
Topical/Cutaneous:
Prophylaxis of gonococcal ophthalmia neonatorum: Store in a tight, light-resistant container. Exposure to light causes silver to oxidise and turn brown.
Disclaimer: This information is independently developed by MIMS based on Silver nitrate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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