Spiramycin


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Cryptosporidiosis; Protozoal infections; Susceptible infections; Toxoplasmosis 6-9 million u/day in 2-3 divided doses. Severe: Up to 15 million u/day in divided doses. IV Cryptosporidiosis; Protozoal infections; Susceptible infections; Toxoplasmosis 1.5 million u 8 hrly. Severe: May double dose.
Dosage Details
Intravenous
Toxoplasmosis, Cryptosporidiosis, Protozoal infections, Susceptible infections
Adult: 1.5 million units by slow infusion every 8 hr, may double the dose in severe infections.

Oral
Cryptosporidiosis, Protozoal infections, Susceptible infections, Toxoplasmosis
Adult: 6-9 million units/day in 2-3 divided doses, increased to 15 million units/day, given in divided doses for severe infections.
Child: and neonates: Chemoprophylaxis of congenital toxoplasmosis: 50 mg/kg bid.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity.
Special Precautions
Hepatic impairment; pregnancy and lactation. Monitor liver function. History of arrhythmias or predisposition to QT interval prolongation.
Adverse Reactions
Nausea, vomiting, abdominal pain, diarrhoea; urticaria, pruritus, macular rashes. Transient paraesthesia may occur.
Potentially Fatal: Pseudomembranous colitis; anaphylaxis; neuromuscular blockade; ventricular arrhythmias, prolongation of QT interval.
Drug Interactions
Decreases carbidopa absorption and levodopa concentrations. Increased risk of ventricular arrhythmias when used with astemizole, cisapride and terfenadine. Risk of acute dystonia when used with fluphenazine.
Action
Description: Spiramycin is a macrolide antibacterial that inhibits protein synthesis by irreversibly binding to the 50S subunit of the ribosomal subunit thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting in stunted cell growth.
Pharmacokinetics:
Absorption: Incompletely absorbed from the GI tract (oral); peak plasma concentrations after 1.5-3 hr.
Distribution: Widely distributed into tissues, enters breast milk. Protein binding: 10-25%.
Metabolism: Metabolised hepatically to active metabolites.
Excretion: Via bile (as metabolites), via urine (10%); 5-8 hr (elimination half-life).
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Spiramycin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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