Tiotixene


Concise Prescribing Info
Indications/Uses
Psychoses.
Dosage/Direction for Use
Adult : PO Initial: 2 mg 3 times/day, increase gradually to 15 mg/day. Severe: 5 mg twice daily till desired response. Usual: 20-30 mg/day. Max: 60 mg/day. IM Initial: 4 mg 2-4 times/day. Max: 30 mg/day.
Dosage Details
Intramuscular
Psychoses
Adult: Initially, 4 mg 2-4 times daily; increased if necessary. Max: 30 mg daily.

Oral
Psychoses
Adult: Mild to moderate: Initially 2 mg tid, increased gradually to 15 mg daily. Severe: 5 mg bid, increased until desired response obtained; usual dose: 20-30 mg daily. Max: 60 mg daily.
Elderly: Dose reduction may be needed.
Special Patient Group
Increased dose requirement in smokers of tobacco or cannabis.
Administration
Should be taken with food. Take w/ meals to reduce GI discomfort.
Contraindications
Coma, CNS depression, circulatory collapse, blood dyscrasias.
Special Precautions
CV disease, parkinson's disease, angle-closure glaucoma, epilepsy, history of seizure or those in alcohol withdrawal, myasthenia gravis, paralytic ileus, prostatic hypertrophy, severe respiratory disease and history of jaundice. Periodic slit lamp examination and monitor for signs of tardive dyskinesia if on prolonged therapy. Possible cross-sensitivity to phenothiazides. Elderly. Pregnancy.
Adverse Reactions
Drowsiness, parkinsonian symptoms, dystonia, akathisia, tardive dyskinesia. CNS effects, GI disturbances, nasal congestion, dry mouth, blurred vision, seizures, hypotension, tachycardia, ECG changes, hyperprolactinaemia, amenorrhoea, gynaecomastia, hypoglycaemia or hyperglycaemia, blood dyscrasias, photosensitisation, contact sensitisation and rashes, purplish pigmentation deposition in various body tissues.
Potentially Fatal: Unexpected death from cardiac arrest or asphyxia, neuroleptic malignant syndrome, anaphylaxis.
Overdosage
Muscle twitching, drowsiness, dizziness, rigidity, weakness, torticollis, tremor, salivation, dysphagia, hypotension, disturbance of gait, CNS depression and coma may occur. Gastric lavage followed by supportive and symptomatic treatment. Value of peritoneal dialysis and haemodialysis unknown. Hypotension and circulatory collapse may be relieved by IV fluids and/or vasopressor e.g. norepinephrine or phenylephrine but not epinephrine.
Drug Interactions
Increase tiotixene serum concentration with enzyme inhibitors e.g. cimetidine, doxepin, isoniazid, nortriptyline, propranolol. Decreased antihypertensive action of guanethidine and other adrenergic neurone blockers. Increased CNS depression with alcohol, general anaesthetics, hypnotics, anxiolytics and opioids. Increased risk of excessive hypotension with other hypotensive drugs. Increased antimuscarinic side effects with TCA, antiparkinsonism drugs. Antagonise effects of dopaminergic drugs. Worsen extrapyridmidal side effects or severe neurotoxicity with concurrent admin of lithium.
Action
Description: Tiotixene is a thioxanthene antipsychotic. It has general properties similar to those of chlorpromazine.
Onset: Distribution Thiothixene is
Pharmacokinetics:
Absorption: Well absorbed from GI tract.
Distribution: Widely distributed into body tissues.
Metabolism: Metabolised in the liver.
Excretion: Excreted mainly in faeces via biliary elimination as unchanged drug and metabolites.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Tiotixene from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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