Zinacef

Zinacef

cefuroxime

Manufacturer:

GlaxoSmithKline

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Cefuroxime Na
Indications/Uses
Resp tract, ENT, UTI, soft tissue, bone & joint infections, obstet & gynaecological infections, pelvic inflammatory disease, gonorrhoea, septicaemia, meningitis, peritonitis. Surgical prophylaxis against infections.
Dosage/Direction for Use
Adult 750 mg IM or IV inj tds. Severe infection 1.5 g IV tds may be increased to 6 hrly frequency. Total daily dose: 3-6 g. Childn & infant 30-100 mg/kg daily in 3 or 4 divided doses. Neonate 30-100 mg/kg daily in 2 or 3 divided doses. Gonorrhoea Adult 1.5 g as single dose given as two 750 mg IM w/ different sites. Meningitis Adult 3 g IV every 8 hr. Childn & infant 150-250 mg/kg daily IV in 3 or 4 divided doses. Neonate 100 mg/kg daily IV. Surgical prophylaxis Abdominal, pelvic & orthopaedic operations: 1.5 g IV w/ anesth induction, may be supplemented w/ two 750 mg IM 8 & 16 hr later. Cardiac, pulmonary, oesophageal & vascular operations: 1.5 g IV w/ anesth induction continuing w/ 750 mg IM tds for 24-48 hr. Total joint replacement: 1.5 g mixed dry w/ methyl methacrylate cement polymer before adding liqd monomer. Adult Pneumonia 1.5 g bd IV or IM for 48-72 hr, followed by oral cefuroxime axetil 500 mg bd for 7-10 days. Acute exacerbation of chronic bronchitis 750 mg bd IV or IM for 48-72 hr, followed by oral cefuroxime axetil 500 mg bd for 5-10 days. CrCl 10-20 mL/min 750 mg bd, CrCl <10 mL/min 750 mg once daily. Patient on haemodialysis Further 750 mg IV or IM at end of each dialysis. Renal failure patient on continuous arteriovenous haemodialysis or high-flux haemofiltration 750 mg bd.
Contraindications
Hypersensitivity to cephalosporins.
Special Precautions
Allergic reactions to penicillins or other β-lactams. Overgrowth of other non-susceptible organisms eg, enterococci & Clostridium difficile. Pseudomembranous colitis. Concurrent use w/ potent diuretics eg, furosemide or aminoglycosides. Preexisting renal impairment. Pregnancy & lactation. Mild to moderate hearing loss in paed patients. Elderly.
Adverse Reactions
Neutropenia, eosinophilia, decreased Hb conc; transient rise in liver enzymes; inj site reaction eg, pain & thrombophlebitis.
Drug Interactions
Lowered oestrogen reabsorption & reduced efficacy of combined OCs.
MIMS Class
Cephalosporins
ATC Classification
J01DC02 - cefuroxime ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.
Presentation/Packing
Form
Zinacef powd for inj (vial) 1.5 g
Packing/Price
1's
Form
Zinacef powd for inj 750 mg
Packing/Price
(vial) 1's
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