HIGHLIGHT
Alzancer

Alzancer

donepezil

Manufacturer:

Nobel Ilac

Distributor:

Multicare

Marketer:

Ambicare
Concise Prescribing Info
Contents
Donepezil HCl
Indications/Uses
Symptomatic treatment of mild to moderate Alzheimer's dementia.
Dosage/Direction for Use
Adult & elderly Initially 5 mg daily as a single dose for at least 1 mth. Can be increased to 10 mg/day as a single dose after evaluation of clinical response obtained w/ 5 mg dose for 1 mth. Max: 10 mg.
Administration
May be taken with or without food: Take at bedtime. Place tab on the tongue & allow to disintegrate before swallowing w/ or w/o water.
Contraindications
Hypersensitivity to donepezil HCl or piperidine derivatives.
Special Precautions
May increase succinylcholine type of muscle relaxation during anaesth. Vagotonic effects in patients w/ sick sinus syndrome & other supraventricular cardiac conduction disorders like SA or AV block. May increase production of gastric acid in patients w/ ulcer history or w/ high risk of ulcer development eg, patients taking concomitant NSAIDs. Bladder outlet obstruction. Generalized convulsions; may induce or increase the extrapyramidal symptoms. Patients w/ history of asthma or obstructive pulmonary disease. Avoid concomitant use w/ other acetylcholinesterase inhibitors, cholinergic system agonists or antagonists. May impair ability to drive & use machines. Hepatic impairment. Pregnancy & lactation. Not recommended in childn.
Adverse Reactions
Insomnia; diarrhoea, nausea, vomiting; muscle cramps; fatigue; headache. Cold; anorexia; hallucination, agitation, aggressive behaviours, abnormal dreams; syncope, dizziness; abdominal discomfort; urticaria, rash; urinary incontinence; pain, weakness; accident.
Drug Interactions
Avoid concomitant use w/ other cholinesterase inhibitors. May decrease levels w/ enzyme inducers like rifampicin, carbamazepine & alcohol. Potential to interact w/ medicines w/ anticholinergic activity. Potential synergistic activity w/ medicines w/ succinylcholine, other agents blocking neuromuscular end plate, or cholinergic agonists or β-blockers having effects on cardiac conduction.
ATC Classification
N06DA02 - donepezil ; Belongs to the class of anticholinesterases. Used in the management of dementia.
Presentation/Packing
Form
Alzancer orodispersible tab 5 mg
Packing/Price
28's
Form
Alzancer orodispersible tab 10 mg
Packing/Price
28's
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