Amsutas

Per 250 mg/125 mg powd for inj Ampicillin Na 250 mg, sulbactam Na 125 mg. Per 500 mg/250 mg powd for inj Ampicillin Na 500 mg, sulbactam Na 250 mg. Per 1 g/500 mg powd for inj Ampicillin Na 1 g, sulbactam Na 500 mg

Infections due to β-lactamase-producing organisms.

1 g/500 mg every 6 hr. Doses may be doubled in severe infections.

Hypersensitivity to penicillins.

Discontinue use if superinfection occurs. Periodically check organ system including renal, hepatic & hematopoietic dysfunction during extended therapy (neonates especially premature & other infant). False +ve glycosuria in urinalysis, using Benedict's & Fehling's reagent & Clinitest. May impair ability to drive or operate machinery.

Skin rashes including urticarial or maculopapular rash.

Decreased renal tubular secretion w/ probenecid. Aminoglycoside by any of the aminopenicillins. Ampicillin: Increased incidence of rashes w/ allopurinol. Substantial mutual inactivation (in vitro) w/ aminoglycosides (administer at separate sites at least 1 hr apart). Additive effects in the alteration of platelet aggregation & coagulation tests w/ anticoagulants. Bactericidal effects may be interfered by bacteriostatic drugs (eg, chloramphenicol, erythromycin, sulfonamides & tetracyclines). May reduce effects of estrogen-containing OCs. May decrease clearance of methotrexate & increase methotrexate toxicity. A transmit decrease in plasma conc of total conjugated estrone & estradiol.

Penicillins

J01CR01 - ampicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.

Rx