Phil Pharmawealth
Concise Prescribing Info
Suxamethonium Cl
Adjunct to general anesth to facilitate endotracheal intubation & to relax skeletal muscle during surgery. Reduce the intensity of muscle contractions of pharmacologically or electrically-induced convulsions.
Dosage/Direction for Use
IV Adult 0.3-1.1 mg/kg. Usually 20-100 mg. Supplementary dose: 50-100% of initial dose at 5-10 min interval. Max total dose: 500 mg/hr given by IV/continuous infusion. Childn 1-12 yr 1 mg/kg. Infant <1 yr 2 mg/kg. IM Adult 3-4 mg/kg. Childn 4 mg/kg. Infant 4-5 mg/kg. Max total dose: 150 mg.
Atypical plasma cholinesterase; patient w/ burns, massive trauma, renal impairment w/ raised plasma K conc, severe chronic sepsis & severe hyperkalemia; penetrating eye injury, raised IOP or glaucoma, incision of the eyeball during eye surgery; bone fracture; history of malignant hyperthermia.
Special Precautions
Reduced plasma cholinesterase activity; previous hypersensitivity to any neuromuscular blocker; cardiac or resp disease. Pregnancy.
Adverse Reactions
Prolonged apnea & resp depression; tachyphylaxis; transient fasciculations; rhabdomyolysis; myoglobinemia & myoglobinuria; post-op muscle pain, transient rise in intragastric pressure & IOP; bradycardia, other arrhythmias & hypotension, cardiac arrest, tachycardia, increased BP; muscarinic effects; hypersensitivity reactions eg, flushing, skin rash, bronchospasm & shock.
Drug Interactions
Anticholinesterases, antiepileptics, antineoplastics, general & local anesth, MAOIs, metoclopramide, sex hormones, sympathomimetics.
ATC Classification
M03AB01 - suxamethonium ; Belongs to the class of choline derivative agents used as peripherally-acting muscle relaxants.
Anekcin inj 20 mg/mL
(vial) 10 mL x 10 × 1's
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