Acid-base disturbances w/ oral carbonic anhydrase inhibitors. May inhibit metabolism w/ CYP3A4 inhibitors eg, ketoconazole, itraconazole, clotrimazole, ritonavir & troleandomycin. Potential additive effect on the known systemic effects w/ carbonic anhydrase inhibitor. Risk of hypotension &/or marked bradycardia w/ oral Ca channel blockers, guanethidine or β-adrenergic blocking agents, antiarrhythmics (including amiodarone), digitalis glycosides or parasympathomimetics. May potentiate hypertensive reaction to sudden w/drawal of clonidine. May potentiate systemic β-blockade effect w/ CYP2D6 inhibitors eg, quinidine, cimetidine, fluoxetine, paroxetine & timolol. May increase hypoglycemic effect of antidiabetic agents. Concomitant use w/ adrenaline may result to mydriasis.