Concise Prescribing Info
Management of HTN & angina pectoris, & as adjunct therapy in symptomatic heart failure.
Dosage/Direction for Use
Hypotension Initially 6.25 mg bid, then increase 1-2 wk to 12.5 mg bid. May increase dose at least 2 wk to 50 mg once daily or in divided doses. Elderly 12.5 mg once daily. Angina pectoris Initially 12.5 mg bid. Increase to 25 mg bid after 2 days. Heart failure Initially 3.125 mg bid. If tolerated, double the dose to 6.25 mg after 2 wk, then increase gradually at intervals of not less than 2 wk. Patient weighing >85 kg Max: 50 mg bid, <65 kg Max: 25 mg bid.
Should be taken with food: Take w/ food to reduce the risk of hypotension.
Hypersensitivity; bronchospasm or asthma, history of obstructive airways disease, hepatic impairment.
Special Precautions
Bronchospasm or asthma to those w/ a history of obstructive airways disease; metabolic acidosis, severe peripheral arterial disease, sinus bradycardia, & 2nd or 3rd-degree atrioventricular block; caution in 1st-degree block; uncontrolled heart failure; phaeochromocytoma.
Adverse Reactions
Heart failure, heart block, & bronchospasm.
Drug Interactions
Enhanced or antagonized hypertensive effect, on carbohydrate metabolism or effect on bronchial β₂ receptors of β₁ & β₂ receptors. Enhanced antihypertensive effects w/ ACEIs, Ca-channel blockers, clonidine & drugs that cause hypotension eg, aldesleukin & general anesth, & NSAIDs. May precipitate bradycardia & heart attack w/ other cardiac depressants eg, antiarrhythmics & rate-limiting Ca channel blockers. Exaggerated hypertensive response & inhibited bronchodilator effects w/ adrenaline. Reduced response on anaphylaxis of adrenaline. Reduced response to insulin & oral hypoglycemic agents in diabetic patients. Reduced absorption w/ Al salts & bile-acid resins eg, colestyramine. Increased metabolism w/ barbiturates & rifampicin. Decreased metabolism w/ cimetidine, erythromycin, fluvoxamine & hydralazine. Decreased hepatic clearance w/ cimetidine & hydralazine.
MIMS Class
ATC Classification
C07AG02 - carvedilol ; Belongs to the class of alpha and beta blocking agents. Used in the treatment of cardiovascular diseases.
Dilabloc tab 6.25 mg
10 × 10's (P7.25/tab)
Dilabloc tab 25 mg
10 × 10's (P12.5/tab)
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