IV/IMAdult 1-2 g as single or 2 divided doses daily. Severe infection Max: 4 g daily. Childn 50-75 mg/kg daily in 2 divided doses. Max: 2 g. Meningitis Childn 100 mg/kg daily in 2 divided doses; sometimes w/ loading dose of 75 mg/kg. Max: 4 g. Gonorrhea 250 mg IM single dose. Surgical inj prophylaxis 1 g single dose, 0.5-2 hr pre-op.
Hypersensitivity to cephalosporins
Avoid prolonged use. Renal failure, hepatic dysfunction. Patients w/ impaired vit K synthesis or low vit K stores. GI disease eg, colitis.
Pain, induration or tenderness at the site of inj. Rash, eosinophilia, thrombocytosis & leukopenia. Diarrhea, elevated SGOT or SGPT & BUN.