RiteMED Captopril

Captopril

Management of HTN, heart failure following MI & diabetic nephropathy.

HTN Initially 25 mg bid or tid. May be increased to 100 mg bid or tid up to 150 mg bid or tid. Max daily dose: 450 mg in divided doses. Patient w/ severe HTN, when temporary discontinuation of current antihypertensive therapy is not practical or desirable, or when prompt titration to more normotensive BP levels is indicated Initially 25 mg bid or tid. Heart failure Initially 25 mg tid. Max daily dose: 450 mg in divided doses. Patient w/ normal or low BP, vigorously treated w/ diuretics & may be hyponatremic &/or hypovolemic Initially 6.25 or 12.5 mg tid. Left ventricular dysfunction after MI Initially 12.5 mg tid after a single dose of 6.25 mg, increased to 25 mg tid. Maintenance dose: 50 mg tid. Diabetic nephropathy 75-100 mg/day in divided doses. Patient w/ severe renal impairment 12.5 mg bid. Elderly w/ reduced renal function & other organ dysfunctions Initially 6.25 mg bid. Childn 12-18 yr Test dose: 0.1 mg/kg (max: 6.25 mg), if tolerated, give 12.5-25 mg bid or tid, max: 150 mg/day in divided doses, 1 mth-12 yr Test dose: 0.1 mg/kg (max: 6.25 mg), if tolerated, give 0.1-0.3 mg/kg bid or tid, max: 6 mg/kg/day in divided doses, 1 mth-1 yr Max: 4 mg/kg/day in divided doses.

Should be taken on an empty stomach: Take 1 hr before meals.

History of angioedema associated w/ previous ACE inhibitor therapy; hereditary/idiopathic angioneurotic edema. Pregnancy & lactation.

Head & neck, intestinal angioedema; anaphylactoid reactions during desensitization, high-flux dialysis & lipoprotein apheresis membrane exposure; neutropenia/agranulocytosis, thrombocytopenia & anemia; collagen vascular disease, immunosuppressant therapy, treatment w/ allopurinol or procainamide, preexisting impaired renal function. Perform WBC & differential counts prior to therapy, every 2 wk during the 1st 3 mth & periodically thereafter. Bilateral renal-artery stenosis or w/ renal artery stenosis of a solitary kidney. Proteinuria, dual blockade of the renin-angiotensin-aldosterone system, hyperkalemia, DM. Heart failure & excessive BP lowering in patients w/ ischemic CV or cerebrovascular disease. Left ventricular valvular & outflow tract obstruction, cardiogenic shock & hemodynamically significant obstruction, aortic stenosis. Discontinue use when jaundice or marked elevations of hepatic enzymes develop. Persistent nonproductive cough, aggravate hypotension caused during procedures. May impair ability to drive or operate machinery. Childn.

CV, nervous system, GI, hematologic, musculoskeletal, metabolic/nutritional, resp, hepatic, skin & appendages, urogenital/reproductive & special senses adverse effects. Angioedema, malaise, fatigue, asthenia, fever.

Ganglionic or adrenergic neuron blocking agents, nitroglycerin or other nitrates, allopurinol, procainamide, cytostatic or immunosuppressive agents (eg, azathioprine), antacids, antidiabetics, clonidine, diuretics (eg, thiazide or loop diuretics), gold, lithium, NSAIDs (eg, aspirin), other antihypertensive agents (eg, β-blockers & long-acting Ca channel blockers), K-sparing diuretics (eg, spironolactone, triamterene or amiloride), K supplements or K-containing salt substitutes, probenecid, TCA, antipsychotics, sympathomimetics.

ACE Inhibitors/Direct Renin Inhibitors

C09AA01 - captopril ; Belongs to the class of ACE inhibitors. Used in the treatment of cardiovascular disease.

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