RiteMED Co-amoxiclav

RiteMED Co-amoxiclav

amoxicillin + clavulanic acid

Manufacturer:

RiteMED

Distributor:

RiteMED
Concise Prescribing Info
Contents
Co-amoxiclav (amoxicillin & clavulanic acid). Per 625 mg tab Amoxicillin 500 mg, clavulanic acid 125 mg. Per 1 g tab Amoxicillin 875 mg, clavulanic acid 125 mg
Indications/Uses
Infections due to β-lactamase-producing strains (where amoxicillin alone is not appropriate) including resp tract, genitourinary & abdominal infections; cellulitis, animal bites, severe dental infection w/ spreading cellulitis.
Dosage/Direction for Use
Adult & childn >12 yr Mild to moderate infections 375 mg 8 hrly or 625 mg 12 hrly. Dental abscess 375 mg 8 hrly for 5 days. Severe infections including chronic & recurrent UTI & lower resp tract infections 625 mg 8 hrly or 1 g 12 hrly. Hemodialysis 375 or 625 mg 24 hrly. Renal impairment CrCl 10-30 mL/min 375 or 625 mg 12 hrly, CrCl <10 mL/min 375 mg 12 hrly.
Administration
May be taken with or without food: Best taken at the start of meals for better absorption & to reduce GI discomfort.
Contraindications
Hypersensitivity to penicillins. Cross-sensitivity w/ other β-lactam antibiotics eg, cephalosporins. Previous history of jaundice/liver impairment associated w/ penicillins. Glandular fever or lymphatic lymphoma.
Special Precautions
Hepatic & renal impairment. Pregnancy & lactation.
Adverse Reactions
Hypersensitivity reactions & GI disturbances. Reversible leukopenia & thrombocytopenia, thrombocytopenic purpura, agranulocytosis, anemia, slight thrombocytosis, eosinophilia, abnormal platelet aggregation, prolonged bleeding & prothrombin time. Dizziness, headache, reversible hyperactivity & convulsions, agitation, anxiety, behavioral changes, confusion, insomnia. Increased AST & ALT, serum bilirubin & alkaline phosphatase; hepatitis, cholestatic jaundice, acute hepatic dysfunction. Acute interstitial nephritis, crystalluria, vag itching, soreness & discharge. Superficial tooth discoloration.
Drug Interactions
Probenecid, allopurinol, methotrexate, OCs, warfarin, disulfiram.
MIMS Class
Penicillins
ATC Classification
J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Presentation/Packing
Form
RiteMED Co-amoxiclav 1 g film-coated tab
Packing/Price
10's (P52.46/film-coated tab, P524.55/box)
Form
RiteMED Co-amoxiclav 625 mg film-coated tab
Packing/Price
15's (P492.19/box, P32.81/film-coated tab)
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in