Potentiated effect w/ insulin & other oral antidiabetics, ACE inhibitors, anabolic steroids & male sex hormones; chloramphenicol, coumarin derivatives, cyclophosphamide. disopyramide, fenfluramine, fenyramidol, fibrates, fluoxetine, guanethidine, ifosfamide, MAOIs, miconazole, fluconazole, para-amino salicylic acid, pentoxifylline, phenylbutazone, azapropazone, oxyphenbutazone, probenecid, quinolones, salicylates, sulfinpyrazone, clarithromycin, sulfonamide antibiotics, tetracyclines, tritoqualine, trofosfamide. Weakened blood-glucose lowering effect w/ acetazolamide, barbiturates, corticosteroids, diazoxide, diuretics, epinephrine & other sympathomimetics, glucagon, laxatives, nicotinic acid, estrogens & progestogens, phenothiazines, phenytoin, rifampicin, thyroid hormones. May lead to either potentiation or weakening of effect w/ H2
receptor antagonists, β-blockers, clonidine & reserpine, acute & chronic alcohol intake. Potentiated or weakened effect of coumarin derivatives. Bile acid sequestrant.