Decreased renal clearance & increased exposure w/ probenecid & other nucleoside analogues. Increased AUC of zidovudine. Increased plasma conc of didanosine. Increased in phenolic glucuronide of mycophenolic acid (MPAG) & ganciclovir concentration w/ oral mycophenolate mofetil. Potential enhancement of toxicity w/ trimethoprim. Synergistic or antagonistic effect w/ other antiretrovirals. Enhanced toxicity w/ dapsone, pentamidine, flucytosine, vincristine, vinblastine, adriamycin, amphotericin B, trimethoprim/sulpha
combinations, nucleoside analogues & hydroxyurea. Imipenem-cilastatin.